GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4660306 | 1 | rs2077808 | chr1:45988115 | CCDC163P | chr1:45960581-45965646:- | -0.79 | -16.21 | 2.35E-45 | Homocysteine levels |
| BLCA | cis | rs882367 | 1 | rs2079795 | chr17:59496649 | C17orf82 | chr17:59489112-59490641:+ | -0.21 | -4.62 | 5.24E-6 | Sitting height ratio |
| BLCA | cis | rs7655841 | 1 | rs2083634 | chr4:129976478 | C4orf33 | chr4:130014829-130033842:+ | -0.32 | -5.36 | 1.41E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs9381040 | 1 | rs2093395 | chr6:41155026 | LOC221442 | chr6:41068773-41108567:+ | -0.24 | -4.19 | 3.47E-5 | Alzheimer's disease (late onset) |
| BLCA | cis | rs9381040 | 1 | rs2093396 | chr6:41155000 | LOC221442 | chr6:41068773-41108567:+ | 0.24 | 4.27 | 2.49E-5 | Alzheimer's disease (late onset) |
| BLCA | cis | rs10461617 | 1 | rs2113078 | chr5:56087190 | C5orf35 | chr5:56205103-56213010:+ | 0.68 | 9.88 | 1.22E-20 | Type 2 diabetes |
| BLCA | cis | rs10461617 | 1 | rs2113079 | chr5:56157951 | C5orf35 | chr5:56205103-56213010:+ | 0.77 | 11.84 | 8.81E-28 | Type 2 diabetes |
| BLCA | cis | rs7714584 | 1 | rs2115069 | chr5:150252365 | LOC134466 | chr5:150310000-150326146:- | 0.49 | 6.25 | 1.07E-9 | Crohn's disease |
| BLCA | cis | rs60843830 | 1 | rs2126129 | chr2:212548 | SH3YL1 | chr2:218138-264810:- | -0.42 | -10.75 | 1.02E-23 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs7112513 | 1 | rs2127905 | chr11:117026374 | PCSK7 | chr11:117075789-117102811:- | -0.41 | -5.13 | 4.7E-7 | Protein quantitative trait loci |
| BLCA | cis | rs9815354 | 1 | rs2128834 | chr3:41862645 | ULK4 | chr3:41288091-42003660:- | 0.6 | 9.42 | 4.5E-19 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs2128835 | chr3:41862873 | ULK4 | chr3:41288091-42003660:- | 0.62 | 9.63 | 8.26E-20 | Diastolic blood pressure |
| BLCA | cis | rs2130392 | 1 | rs2130392 | chr4:185639169 | MLF1IP | chr4:185615220-185655286:- | -0.45 | -11.33 | 7.65E-26 | Kawasaki disease |
| BLCA | cis | rs12045807 | 1 | rs2134688 | chr1:150816886 | HORMAD1 | chr1:150670542-150693352:- | 0.38 | 3.95 | 9.36E-5 | Congenital left-sided heart lesions |
| BLCA | cis | rs9309473 | 1 | rs2140195 | chr2:73702344 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.94 | 6.4E-9 | Metabolite levels |